ea0005oc10 | Cardiovascular Endocrinology | BES2003
McBride M
, Carr F
, Graham D
, Anderson N
, Clark J
, Lee W
, Charchar F
, Brosnan M
, Dominiczak A
Objective. The aims of our study were to utilise a combination of high fidelity phenotyping, microarray gene expression profiling and conserved synteny mapping between rodent and human genomes to identify genetic determinants underlying human hypertension.Methods. We used the stroke-prone spontaneously hypertensive rat (SHRSP) and a congenic strain (SP.WKYGla2c*) produced by introgressing a quantitative trait locus responsible for blood pressure regulation on rat chromosom...